Lung Cancer
Overview
Lung cancer is a disease that begins when abnormal cells grow uncontrollably in the lungs, the organs responsible for bringing oxygen into the body and removing carbon dioxide. It is one of the most common cancers in the United States and remains the leading cause of cancer-related death worldwide.
While smoking is the strongest risk factor, lung cancer can also occur in people who have never smoked. The risk increases with the number of years and amount a person has smoked, but quitting at any stage can significantly reduce the chance of developing the disease. Early detection and advances in treatment continue to improve outcomes, and our multidisciplinary teams use the latest diagnostic and therapeutic approaches to support patients at every step.
Signs & Symptoms
Lung cancer often causes no symptoms in its early stages. Most signs and symptoms appear after the disease has progressed, and they may be similar to those caused by other, more common conditions. Still, any persistent or worsening symptom should be evaluated by a doctor.
Common signs and symptoms may include:
- A persistent cough or a new cough that does not go away
- Coughing up blood, even in small amounts
- Shortness of breath
- Chest pain or discomfort
- Hoarseness
- Unexplained weight loss
- Fatigue
- Bone pain
People with cancer that has spread to the lungs (secondary or metastatic lung cancer) may experience similar symptoms, especially a persistent cough, breathlessness, or coughing up blood-tinged phlegm. Symptoms can overlap with infections or other noncancerous conditions, so it's important to seek medical advice if concerns arise.
Causes
Lung cancer develops when cells in the lungs acquire changes in their DNA that allow them to grow uncontrollably. Smoking is the leading cause of lung cancer, but the disease can also occur in people who have never smoked or had significant exposure to secondhand smoke. In many of these cases, the exact cause is unknown.
How smoking contributes to lung cancer
Cigarette smoke contains numerous carcinogens that damage the cells lining the lungs. With each inhalation, these harmful substances injure lung tissue. The body can repair some of this damage at first, but repeated exposure creates more genetic changes over time. Eventually, damaged cells may begin to grow and divide in abnormal ways, leading to cancer.
Risk Factors
Certain factors can increase the likelihood of developing lung cancer. Some are related to lifestyle or environmental exposure, while others are not within your control. Common risk factors include:
- Smoking: The leading risk factor for lung cancer. Risk increases with the number of cigarettes smoked and the length of time spent smoking. Quitting smoking at any age lowers your risk.
- Secondhand smoke: Regular exposure to another person's smoke can raise your risk, even if you have never smoked yourself.
- Prior chest radiation: Radiation therapy used to treat other cancers can increase the chance of developing lung cancer later in life.
- Radon exposure: Radon gas can build up in homes and buildings. Long-term exposure to high levels increases lung cancer risk.
- Workplace carcinogens: Exposure to substances like asbestos, arsenic, chromium, or nickel can elevate risk, especially when combined with smoking.
- Family history: Having a close relative with lung cancer may increase your risk, suggesting a possible inherited or shared environmental component.
Types of Lung Cancer
Lung cancer is classified based on how the cancer cells look under a microscope. Identifying the type helps guide treatment options and predict how the disease may behave. The two main types are:
- Non-Small Cell Lung Cancer (NSCLC)
- Small Cell Lung Cancer (SCLC)
| Non-Small Cell Lung Cancer (NSCLC) | Small Cell Lung Cancer (SCLC) |
|---|---|
| The most common type of lung cancer, making up about 85% of cases. NSCLC grows and spreads more slowly than small cell lung cancer. | A less common but more aggressive type that accounts for about 15% of lung cancers. |
| Main subtypes include: Adenocarcinoma, Squamous cell carcinoma, and Large cell carcinoma. | Almost always linked to heavy smoking. |
| Adenocarcinoma: Often begins in mucus-producing cells; now the most common type in both smokers and people who have never smoked. | Tends to grow and spread rapidly, so treatment often begins quickly after diagnosis. |
| Squamous cell carcinoma: Starts in the cells lining the airways; strongly linked to smoking. | |
| Large cell carcinoma: A less common form with larger, more abnormal-appearing cells; can grow quickly. |
Other Rare Cancers
While SCLC and NSCLC are the two primary types of lung cancer, other rare cancers can develop in or around the lungs but are not classified within these main categories.
A rare cancer affecting the lining of the lungs (pleura).
- Most often caused by asbestos exposure.
- Behaves differently from typical lung cancers and requires specialized management.
Uncommon neuroendocrine tumors that can develop in the lungs.
- Usually grow more slowly than other lung cancers.
- Often diagnosed earlier because they may cause airway blockage symptoms.
Cancer that has spread to the lungs from another part of the body (such as the colon, breast, kidney, or melanoma).
- Managed based on where the cancer originated rather than as primary lung cancer.
Treatments & Services
Treatment Options
Lung cancer treatment depends on the type of cancer, its stage, and your overall health. Approaches may include treatments that target the tumor directly or therapies that help control the spread of disease. Your care team will create a personalized plan based on your specific diagnosis.
Service Options
Find Care
Early evaluation and timely treatment can make a meaningful difference in outcomes for lung cancer. Our specialists provide coordinated care at locations close to home, offering access to advanced testing, treatment technologies, and multidisciplinary expertise.
If you have concerns about lung cancer symptoms or risk, or if you need guidance after a new diagnosis, our teams are here to help you take the next step.
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